sertraline for Pe Info



Sertraline treats several conditions, namely: depression, panic disorder, obsessive-compulsive disorder (OCD), premenstrual dysphoric disorder (PMDD), social anxiety disorder (SAD), post-traumatic stress disorder (PTSD), and premature ejaculation (PE).
When it comes to treating premature ejaculation, finding the exact cause is key to treatment. Though the exact cause may not be known, in many cases, serotonin could play a role. Serotonin is a chemical that plays a key role in many body functions. High levels of serotonin helps increase ejaculation time, whereas low levels of serotonin can shorten it and lead to premature ejaculation.
Several studies on men and women taking antidepressants documented that they tend to have delayed orgasms. Fluoxetine, clomipramine, paroxetine, and sertraline (among others) affect serotonin levels. Doctors then began to prescribe these drugs “off-label” for the treatment of premature ejaculation. However, this medication will only be made available to you with a doctor’s prescription.
Medications for premature ejaculation can be taken either daily or just before sex. But what most doctors suggest is one dose at least 4-8 hours before sexual activity. If Sertraline is taken daily, it could have some adverse effects and the possibility for drug interactions could increase. Our Thrones Health physicians DO NOT recommend using Sertraline on a daily basis, preferring an “an needed” only approach to treatment.

How to Take Sertraline Properly (for Premature Ejaculation)

Take this medicine as prescribed and as directed by your physician. Keep in mind to not take more than what is prescribed, don’t take it more often, and don’t take it for a much longer period than your doctor advised. This medicine comes with a guide. Make sure to read the package label and understand this information before taking Sertraline. If you have questions, it is best to ask your doctor. Sertraline tablets may also be taken with or without food.

The Right Dose of Sertraline for Premature Ejaculation

Our physicians here at Thrones Health recommend taking a single 50mg tablet of Sertraline at least 4-8 hours before sexual activity. Initially, you may be given a maximum of 5 tablets per month to get you started. When you start, we will NOT recommend daily use of Sertraline for premature ejaculation treatment.

How to Properly Store Sertraline

Always store Sertraline within a closed container at a room temperature, away from direct light, heat, and moisture.

Before You Use Sertraline for Premature Ejaculation

Before using any medicine, always weigh the potential risks against the potential benefits. This is a decision your doctor will often make for you which results in the prescription medication. For Sertraline, consider the following:


Let your doctor know in advance if you have experienced any allergic reactions to other medicines. If you have particular allergies with food, animals, and substances (dyes, preservatives), your doctor has to know this information, too. For non-prescription medicines, make sure to read the label carefully, as well as the package ingredients.

Older Population

Appropriate studies that have been conducted to date have not demonstrated any geriatric-specific problems that may arise and limit the use of Sertraline in older adults. But generally, elderly patients could be more sensitive to the medicine’s effects compared to younger patients. They are also more likely to develop hyponatremia (low sodium in the blood) – which requires caution and dosing adjustments for patients taking Sertraline.

Drug Interactions with Sertraline

Drug interactions with Sertraline may be likely, and is more common if Sertraline is taken on a daily basis. At Thrones Health, we do NOT recommend the daily use of Sertraline for Premature Ejacultation. There are cases where medicines used simultaneously could create an interaction, and in some instances, even two different medicines may be used together despite an interaction that the drugs could cause. This would be determined by your doctor, including extra precautions necessary and any change in dosage that will be given to you. When taking Sertraline, it is critical for your healthcare provider to know if you are also taking any one of the medicines listed herein. These interactions have been selected based on potential significance only and are not all-inclusive.
Taking Sertraline with any one of these medicines could create more side effects, however, in some cases, using both drugs would still be the best treatment for your case. Both medicines may be prescribed to you together, but it is your doctor who will determine any changes in the dosage or how frequently you need to take one or both of them:
Using Sertraline with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines:
Using Sertraline with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines:

Other Interactions

There are specific medicines that should not be used around the time of eating as these could create certain interactions with the food. In the same way, using tobacco or alcohol when taking medicines could also cause harmful interactions. These specific interactions have been selected based on potential significance and are not all-inclusive.
If you use this medicine with any of the following, it may cause certain side effects, that could be unavoidable. Used together, your doctor may change dose, how often you need to take this medicine, and give you special instructions in terms of taking it with certain food, alcohol, or tobacco.

Grapefruit Juice

If you are not sure of a potential drug interaction with Sertraline, seek advice from your doctor.
You may also check out the resource ONLINE DRUG-TO-DRUG INTERACTION CHECKER.

Important Medical Problems

Other medical conditions that you may have could affect the use of Sertraline. Inform your doctor if any of these medical conditions are a problem for you:

Bipolar disorder (a certain type of mood disorder that comes with mania and depression),

Bleeding problems or

Diabetes or

Glaucoma, angle-closure, or history of or

Hyponatremia (low sodium in the blood) or

Mania or hypomania, history of or

Any history of purpura (a purplish / brownish-red skin discoloration)

Any history of seizures – could make the condition worse (use with caution)

Liver disease – effects may be increased due to slower pace of removal of the medicine from the body (use with caution)

Special Precautions

Make sure to NOT take sertraline with any of these: phenelzine [Nardil®], monoamine oxidase (MAO) inhibitor (e.g., isocarboxazid [Marplan®], tranylcypromine [Parnate®]), selegiline[Eldepryl®]
Make sure to NOT start sertraline within 2 weeks after you stop any MAO inhibitor. Just wait 2 weeks after stopping sertraline before taking an MAO inhibitor. If you take them together or do not wait for 2 weeks, you may be at risk of developing confusion, agitation, restlessness, sudden high body temperature, stomach or intestinal symptoms, severe convulsions, and high blood pressure
Sertraline could cause a serious condition known as Serotonin Syndrome if taken with some medicines. Do NOT use sertraline with any of the following: fentanyl (Abstral®, Duragesic®), St. John’s wort, linezolid (Zyvox®), lithium (Eskalith®, Lithobid®), tryptophan, buspirone (Buspar®), methylene blue injection, or some migraine or pain relief medicines (e.g., rizatriptan, sumatriptan, tramadol, Frova®, Imitrex®, Maxalt®, Relpax®, Ultram®, Zomig®). Always check with your doctor first before taking any other medicines with Sertraline.
Setraline could be extremely sensitive and may trigger suicidal thoughts in some children, teenagers, and young adults. Inform your doctor once you start feeling more depressed, and thoughts that encourage self-harm. Take note and report thoughts, feelings, or behaviors that bother you, especially if they are unusual, new, or escalate quickly. Also make sure that the doctor knows in case you find trouble sleeping, or that you get easily upset, get a huge boost in energy, or start acting recklessly. If you have sudden, strong feelings that make you feel angry, nervous, restless, violent, or scared, let your doctor know. In case you or anyone in your family has bipolar disorder (manic-depressive) or has tried committing suicide, relay this information to your doctor as well.
Sertraline could cause hyponatremia (low sodium in the blood), although this is more common amongst elderly patients, mostly the people taking diuretic medicines for high blood pressure, or people with small amounts of fluid in the body caused by severe diarrhea or vomiting. Consult with your doctor immediately in case you have trouble concentrating, experience headaches, confusion, weakness, memory problems, or general unsteadiness.
Sertraline could also affect blood sugar levels. For diabetic patients who notice a change in your blood or glucose urine test results, consult with your doctor right away. Additionally, patients taking Sertraline should not be drinking alcohol.
Sertraline causes some people to have trouble with thinking and comprehension, easily become drowsy, and encounter problems with movement. For your safety, don’t use this medicine before conducting activities such as driving, using machineries, and any other activity that could become hazardous if you’re not well-coordinated or highly alert.
Before conducting any medical tests, inform the doctor in charge regarding your use of this medicine. Some of the lab test results could end up affected by this particular medicine.

What If I Overdose?

Overdose can happen. When this happens, seek immediate medical attention right away or contact the Poison Helpline at 1-800-222-1222
For more information, learn more about Sertraline by accessing the Prescriber’s Digital Reference (